ZCCHC6 antibody

Catalog No. ABIN7121053

This Rabbit Polyclonal antibody specifically detects ZCCHC6 in WB, IP and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ZCCHC6 antibody (ABIN7121053)

Target: ZCCHC6 (Zinc Finger, CCHC Domain Containing 6 (ZCCHC6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZCCHC6 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Product Details anti-ZCCHC6 Antibody

Purpose: TUT7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: zinc finger, CCHC domain containing 6

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:500-1:5000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ZCCHC6

Target: ZCCHC6 (Zinc Finger, CCHC Domain Containing 6 (ZCCHC6))

Alternative Name: TUT7

Background:

Synonyms: Terminal uridylyltransferase 7 (TUTase 7)|Zinc finger CCHC domain-containing protein 6|TUT7|HS2|KIAA1711|ZCCHC6

Background: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:19703396, PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets(PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A(PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Molecular Weight: 171 kDa

Gene ID: 79670

UniProt: Q5VYS8