ERAS antibody (AA 20-120) (Biotin)

Catalog No. ABIN708163

This Rabbit Polyclonal antibody specifically detects ERAS in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for ERAS antibody (AA 20-120) (Biotin) (ABIN708163)

Target: ERAS (ES cell expressed Ras (ERAS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERAS antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ERAS Antibody (Biotin)

Binding Specificity: AA 20-120

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERAS/HRAS2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ERAS

Target: ERAS (ES cell expressed Ras (ERAS))

Alternative Name: ERAS/HRAS2

Background:

Synonyms: E ras, E-Ras, ecat5, Embryonic stem cell expressed Ras, Embryonic stem cell-expressed Ras, Eras, ES cell expressed Ras, GTPase ERas, Ha-Ras2, HRAS2, HRASP, MGC126691, MGC126693, OTTHUMP00000065857, RASE_HUMAN, Small GTPase protein E Ras, v Ha ras Harvey rat sarcoma viral oncogene homolog pseudogene, v Ha ras Harvey rat sarcoma viral oncogene homolog 2.

Background: ERAS belongs to the small GTPase superfamily. Ras family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. The ERas gene is expressed in embryonic stem (ES) cells and promotes their in vitro proliferation and tumorigenicity. ERas-null ES cells maintain pluripotency but show significantly reduced growth and tumorigenicity, which are rescued by expression of ERas complementary DNA or by activated phosphatidylinositol-3-OH kinase.

Gene ID: 3266