NAC1 antibody

Catalog No. ABIN7126218

Product Details anti-NAC1 Antibody

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NAC1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: The BTB (broad-complex, tramtrack and bric a brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. BTBD14B (BTB/POZ domain-containing protein 14B), also known as NACC1 (nucleus accumbens associated 1), BEND8 or NAC1, is a 527 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one BTB (POZ) domain. Existing as a homo-oligomer that interacts with HDAC3 and HDAC4, BTBD14B functions as a transcriptional repressor that influences the transcriptional activity of CRIF1 and is required for proteasome recruitment to the nucleus and cytoplasm in dendritic spines. BTBD14B is overexpressed in multiple carcinomas, suggesting a role in tumor development and metastasis.

Cross-Reactivity (Details): Human

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human NACC1 protein

Isotype: IgG2a

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa, MCF7 or K562 cells.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for NAC1

Target: NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))

Alternative Name: NACC1 (NACC1 Products)

Synonyms: BEND8 antibody, BTBD14B antibody, BTBD30 antibody, NAC-1 antibody, NAC1 antibody, NACC1 antibody, 2010001H03Rik antibody, 4930511N13Rik antibody, Btbd14b antibody, Nac1 antibody, Nac-1 antibody, nucleus accumbens associated 1 antibody, nucleus accumbens associated 1, BEN and BTB (POZ) domain containing antibody, NACC1 antibody, Nacc1 antibody

Background: BEND8, BTB Domain Containing 14B, BTB/POZ domain-containing protein 14B, btbd14b, NAC-1, NAC1, Nucleus accumbens-associated protein 1,NACC1 / Nac1 / BTBD14B
Cellular localisation: Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation.

Molecular Weight: 57kDa

Gene ID: 112939, 531614

UniProt: Q96RE7