BCL11A antibody
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- Target See all BCL11A Antibodies
- BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This BCL11A antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Coating (Coat), Blocking Peptide (BP)
- Specificity
- Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.
- Cross-Reactivity (Details)
- Human. Predicted to react in Mouse and Rat.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human BCLL1A protein
- Isotype
- IgG2a
- Top Product
- Discover our top product BCL11A Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL),Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Expressed in all tissues except in cells of the B and T lineage.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
- Alternative Name
- BCL11A (BCL11A Products)
- Synonyms
- 2810047E18Rik antibody, BCL-11A antibody, Ctip1 antibody, D930021L15Rik antibody, Evi9 antibody, Evi9a antibody, Evi9b antibody, Evi9c antibody, mKIAA1809 antibody, BCL11A-L antibody, BCL11A-S antibody, BCL11A-XL antibody, BCL11a-M antibody, CTIP1 antibody, EVI9 antibody, HBFQTL5 antibody, ZNF856 antibody, bcl11a antibody, wu:fi09f10 antibody, zgc:136898 antibody, B cell CLL/lymphoma 11A (zinc finger protein) antibody, B-cell CLL/lymphoma 11A antibody, B-cell CLL/lymphoma 11A L homeolog antibody, B-cell CLL/lymphoma 11Aa antibody, Bcl11a antibody, BCL11A antibody, bcl11a.L antibody, bcl11aa antibody
- Background
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B cell CLL/lymphoma 11A isoform 2, B-cell lymphoma/leukemia 11A, C2H2 type zinc finger protein, COUP-TF-interacting protein 1, CTIP1, Ecotropic viral integration site 9 protein homolog, EVI-9, Zinc finger protein 856, ZNF856,BCL11A / CTIP1 (Transcription Factor)
Cellular localisation: Cytoplasm. Nucleus. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles. - Molecular Weight
- 91.2kDa
- Gene ID
- 53335, 370549
- UniProt
- Q9H165
- Pathways
- Regulation of Cell Size
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