Recombinant MLKL antibody (pSer358)

Catalog No. ABIN7127713

This anti-MLKL antibody is a Rabbit Monoclonal antibody detecting MLKL in ELISA and IHC. Suitable for Human.

Quick Overview for Recombinant MLKL antibody (pSer358) (ABIN7127713)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MLKL antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 4A6

Product Details anti-MLKL Antibody

Binding Specificity: pSer358

Cross-Reactivity: Human

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Phospho-MLKL (S358)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Alternative Name: MLKL

Background:

Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Aliases: Mixed lineage kinase domain-like protein, hMLKL, MLKL

UniProt: Q8NB16