Recombinant SMC1A antibody (pSer957)

Catalog No. ABIN7127751

The Rabbit Monoclonal anti-SMC1A antibody has been validated for WB and ELISA. It is suitable to detect SMC1A in samples from Human.

Quick Overview for Recombinant SMC1A antibody (pSer957) (ABIN7127751)

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SMC1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1F9

Product Details anti-SMC1A Antibody

Binding Specificity: pSer957

Cross-Reactivity: Human

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Phospho-SMC1A (S957)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMC1A

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Alternative Name: SMC1A

Background:

Background: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Aliases: Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, Sb1.8, SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1

UniProt: Q14683

Pathways: Stem Cell Maintenance