SLC12A1 antibody

Catalog No. ABIN7131078

The Rabbit Polyclonal anti-SLC12A1 antibody is suitable to detect SLC12A1 in samples from Human. It has been validated for WB, IHC and ELISA.

Quick Overview for SLC12A1 antibody (ABIN7131078)

Target: SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC12A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SLC12A1 Antibody

Purpose: SLC12A1 Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human SLC12A1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:  pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SLC12A1

Target: SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))

Alternative Name: SLC12A1

Background:

Background: This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Aliases: BSC1 antibody, Bumetanide sensitive sodium 3 antibody, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 antibody, Kidney specific Na K Cl symporter antibody, Kidney-specific Na-K-Cl symporter antibody, MGC48843 antibody, Na K 2Cl cotransporter antibody, NKCC2 antibody, potassiumchloride cotransporter 2 antibody, S12A1_HUMAN antibody, Slc12a1 antibody, sodium potassium chloride cotransporter 2 antibody, solute carrier family 12 (sodium/potassium/chloride transporters) antibody, Solute carrier family 12 member 1 antibody

UniProt: Q13621