MAPT antibody (AA 725-729)

Catalog No. ABIN7138004

This Rabbit Polyclonal antibody specifically detects MAPT in WB and ELISA. It exhibits reactivity toward Rat.

Quick Overview for MAPT antibody (AA 725-729) (ABIN7138004)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MAPT Antibody

Binding Specificity: AA 725-729

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Alternative Name: Mapt

Background:

Background: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Johnson , G.V. and Stoothoff , W.H. (2004) J. Cell Sci. 117, 5721-5729.
Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476.
Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.

Aliases: Mapt antibody, Mtapt antibody, Tau antibody, Microtubule-associated protein tau antibody, Neurofibrillary tangle protein antibody, Paired helical filament-tau antibody, PHF-tau antibody

UniProt: P19332

Pathways: MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size