GRIPAP1 antibody (AA 814-818)

Catalog No. ABIN7138016

This Rabbit Polyclonal antibody specifically detects GRIPAP1 in WB and ELISA. It exhibits reactivity toward Rat.

Quick Overview for GRIPAP1 antibody (AA 814-818) (ABIN7138016)

Target: GRIPAP1 (GRIP1 Associated Protein 1 (GRIPAP1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIPAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GRIPAP1 Antibody

Binding Specificity: AA 814-818

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around aa. 814-818(Q-E-I-V-R ) derived from Rat GRASP.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GRIPAP1

Target: GRIPAP1 (GRIP1 Associated Protein 1 (GRIPAP1))

Alternative Name: Gripap1

Background:

Background: GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid proteinencoded by the human gene GRASP . GRASP is a scaffold protein that com-prises multiple protein-interacting domains, including a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipperregion and a carboxyl-terminal PDZ-binding motif. GRASP is involved with intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASP forms a heteromer composed of GRASP , PSCD2 and at least one mGluR-1. It also interacts with PSCD3, mGluR-2, mGluR-3 and mGluR-5. GRASP is highly expressed in brain and has lower levels of expression in lung, heart, embryo, kidney and ovary.

Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y.and Nakanishi, S. 2002. Tamalin, J. Neurosci. 22: 280-1289.
Hall, B.S., Gabernet-Castello, C., Voak, A., Goulding, D., Natesan, S.K. and Field, M.C. 2006. J. Biol. Chem. 281: 27600-27612.
Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K. and Jingami, H. 2007. Crystal structures of autoinhibitory PDZ domain of Tamalin EMBO J.26: 2192-2205.

Aliases: Gripap1 antibody, Grasp1GRIP1-associated protein 1 antibody, GRASP-1) [Cleaved into: GRASP-1 C-terminal chain antibody, 30 kDa C-terminus form)] antibody

UniProt: Q9JHZ4

Pathways: SARS-CoV-2 Protein Interactome