ILK antibody (pSer246)

Catalog No. ABIN7138506

The Rabbit Polyclonal anti-ILK antibody has been validated for ELISA and IHC. It is suitable to detect ILK in samples from Human.

Quick Overview for ILK antibody (pSer246) (ABIN7138506)

Target: ILK (Integrin-Linked Kinase (ILK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ILK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-ILK Antibody

Binding Specificity: pSer246

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 246(I-F-S(p)-H-P) derived from Human ILK.

Isotype: IgG

Application Details

Application Notes: IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ILK

Target: ILK (Integrin-Linked Kinase (ILK))

Alternative Name: ILK

Background:

Background:

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Hannigan G.E., Nature 379:91-96(1996).
Janji B., Oncogene 19:3069-3077(2000).
Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

Aliases: 59 kDa serine/threonine protein kinase antibody, 59 kDa serine/threonine-protein kinase antibody, DKFZp686F1765 antibody, Epididymis secretory protein Li 28 antibody, HEL S 28 antibody, ILK 1 antibody, ILK 2 antibody, ILK antibody, ILK-1 antibody, ILK-2 antibody, ILK_HUMAN antibody, ILK1 antibody, ILK2 antibody, Integrin linked kinase 2 antibody, Integrin linked Kinase antibody, Integrin linked protein kinase antibody, Integrin-linked protein kinase antibody, p59 antibody, p59ILK antibody

UniProt: Q13418

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration