HNF4A antibody (pSer304)

Catalog No. ABIN7138538

This Rabbit Polyclonal antibody specifically detects HNF4A in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for HNF4A antibody (pSer304) (ABIN7138538)

Target: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNF4A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HNF4A Antibody

Binding Specificity: pSer304

Purpose: Phospho-HNF4A (Ser304) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 304 (L-R-S(p)-Q-V)derived from Human HNF4a.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HNF4A

Target: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Alternative Name: HNF4A

Background:

Background: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes,including hepatocyte nuclear factor 1 a, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.

Kritis A.A,et al.Gene 173:275-280(1996)
Drewes T,et al.Mol. Cell. Biol. 16:925-931(1996)
Yamagata K,et al.Nature 384:458-460(1996)
Tanaka T,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases

Aliases: FLJ39654 antibody, FRTS4 antibody, Hepatic nuclear factor 4 alpha antibody, Hepatocyte nuclear factor 4 alpha antibody, Hepatocyte nuclear factor 4 antibody, Hepatocyte nuclear factor 4-alpha antibody, HNF 4 alpha antibody, HNF 4 antibody, HNF-4-alpha antibody, HNF4 antibody, HNF4A antibody, HNF4A_HUMAN antibody, HNF4a7 antibody, HNF4a8 antibody, HNF4a9 antibody, Hnf4alpha antibody, HNF4alpha10/11/12 antibody, MODY 1 antibody, MODY antibody, MODY1 antibody, NR2A1 antibody, NR2A21 antibody, Nuclear receptor subfamily 2 group A member 1 antibody, OTTHUMP00000031060 antibody, OTTHUMP00000031062 antibody, TCF 14 antibody, TCF antibody, TCF-14 antibody, TCF14 antibody, Tcf4 antibody, Transcription factor 14, hepatic nuclear factor antibody, Transcription factor 14 antibody, Transcription factor HNF 4 antibody, Transcription factor HNF-4 antibody, Transcription factor HNF4 antibody

UniProt: P41235

Pathways: AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process