AIRE antibody (pSer156)

Catalog No. ABIN7138747

The Rabbit Polyclonal anti-AIRE antibody (ABIN7138747) specifically detects AIRE in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for AIRE antibody (pSer156) (ABIN7138747)

Target: AIRE (Autoimmune Regulator (AIRE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIRE antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-AIRE Antibody

Binding Specificity: pSer156

Purpose: Phospho-AIRE (Ser156) Antibody

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine156 P-G-S(p)-Q-L) derived from Human AIRE.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AIRE

Target: AIRE (Autoimmune Regulator (AIRE))

Alternative Name: AIRE

Background:

Background:

The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized.

Nagamine K., Nat. Genet. 17:393-398(1997).
Aaltonen J., Nat. Genet. 17:399-403(1997).
Hattori M., Nature 405:311-319(2000).

Aliases: AIRE antibody, AIRE_HUMAN antibody, AIRE1 antibody, APECED antibody, APECED protein antibody, APS1 antibody, APSI antibody, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody, Autoimmune regulator antibody, Autoimmune regulator protein antibody, PGA1 antibody

UniProt: O43918

Pathways: Chromatin Binding