XIAP antibody (pSer87)

Catalog No. ABIN7138763

This Rabbit Polyclonal antibody specifically detects XIAP in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for XIAP antibody (pSer87) (ABIN7138763)

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XIAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-XIAP Antibody

Binding Specificity: pSer87

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine87(K-V-S(p)-P-N) derived from Human XIAP .

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for XIAP

Target: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Alternative Name: XIAP

Background:

Background:

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.

Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12.

Aliases: AP 13 antibody, API3 antibody, Apoptosis Inhibitor 3 antibody, Baculoviral IAP repeat containing 4 antibody, Baculoviral IAP Repeat Containing Protein 4 antibody, Baculoviral IAP repeat-containing protein 4 antibody, BIRC 4 antibody, BIRC4 antibody, E3 ubiquitin-protein ligase XIAP antibody, hIAP-3 antibody, hIAP3 antibody, HILP antibody, IAP 3 antibody, IAP like protein antibody, IAP-3 antibody, IAP-like protein antibody, IAP3 antibody, ILP 1 antibody, ILP antibody, ILP1 antibody, Inhibitor of apoptosis protein 3 antibody, Inhibitor of Apoptosis X Linked antibody, Mammalian IAP Homologue A antibody, MIHA antibody, X linked IAP antibody, X linked inhibitor of apoptosis antibody, X linked inhibitor of apoptosis E3 ubiquitin protein ligase antibody, X linked inhibitor of apoptosis protein antibody, X-linked IAP antibody, x-linked inhibitor of apopotosis proteins antibody, X-linked inhibitor of apoptosis protein antibody, Xiap antibody, XIAP_HUMAN antibody, XLP2 antibody

UniProt: P98170

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis