Claudin 5 antibody (pTyr217)

Catalog No. ABIN7138958

This Rabbit Polyclonal antibody specifically detects Claudin 5 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Claudin 5 antibody (pTyr217) (ABIN7138958)

Target: Claudin 5 (CLDN5)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 5 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-Claudin 5 Antibody

Binding Specificity: pTyr217

Purpose: Phospho-CLDN5 (Tyr217) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 217 (K-K-N-Y(p)-V) derived from Human Claudin 5.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Claudin 5

Target: Claudin 5 (CLDN5)

Alternative Name: CLDN5

Background:

Background:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.

Sirotkin H., Genomics 42:245-251(1997).
Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Aliases: Androgen withdrawal and apoptosis induced protein RVP1 like antibody, AWAL antibody, BEC 1 antibody, BEC1 antibody, Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) antibody, Claudin-5 antibody, Claudin5 antibody, CLD5_HUMAN antibody, CLDN 5 antibody, Cldn5 antibody, CPETR L1 antibody, CPETRL 1 antibody, CPETRL1 antibody, TMDVCF antibody, TMVCF antibody, Transmembrane protein deleted in VCFS antibody, Transmembrane protein deleted in velocardiofacial syndrome antibody

UniProt: O00501

Pathways: Hepatitis C