BCR antibody (pTyr360)

Catalog No. ABIN7138990

The Rabbit Polyclonal anti-BCR antibody (ABIN7138990) specifically detects BCR in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for BCR antibody (pTyr360) (ABIN7138990)

Target: BCR (Breakpoint Cluster Region (BCR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BCR Antibody

Binding Specificity: pTyr360

Purpose: Phospho-BCR (Tyr360) Antibody

Cross-Reactivity: Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 360 (T-T-Y(p)-R-M) derived from Human Bcr.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BCR

Target: BCR (Breakpoint Cluster Region (BCR))

Alternative Name: BCR

Background:

Background:

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Perazzona B, et al. (2008) Oncogene 27, 2208-14. Sun T, Campbell M, Gordon W, Arlinghaus RB (2001) Biopolymers 60, 61-75 . Wu Y, Liu J, Arlinghaus RB (1998)Oncogene 16, 141-6.

Aliases: ALL antibody, bcr antibody, BCR/ABL FUSION GENE, INCLUDED antibody, BCR/FGFR1 chimera protein antibody, BCR/FGFR1 FUSION GENE, INCLUDED antibody, BCR/PDGFRA FUSION GENE, INCLUDED antibody, BCR_HUMAN antibody, BCR1 antibody, Breakpoint cluster region antibody, Breakpoint cluster region protein antibody, CML antibody, D22S11 antibody, D22S662 antibody, FGFR1/BCR chimera protein antibody, PHL antibody, Renal carcinoma antigen NY-REN-26 antibody

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling