Phospholipase C gamma 2 antibody (pTyr753)

Catalog No. ABIN7139060

This Rabbit Polyclonal antibody specifically detects Phospholipase C gamma 2 in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for Phospholipase C gamma 2 antibody (pTyr753) (ABIN7139060)

Target: Phospholipase C gamma 2 (PLCG2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholipase C gamma 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Phospholipase C gamma 2 Antibody

Binding Specificity: pTyr753

Purpose: Phospho-PLCG2 (Tyr753) Antibody

Cross-Reactivity: Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 753 (S-L-Y(p)-D-V) derived from Human PLCg2.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Phospholipase C gamma 2

Target: Phospholipase C gamma 2 (PLCG2)

Alternative Name: PLCG2

Background:

Background: The production of the second messenger molecules diacylglycerol. (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Kim YJ, et al. (2004) Mol Cell Biol 24: 9986-9999
Humphries LA, et al. (2004) J Biol Chem 279 : 37651-37661
Suzuki-Inoue K, et al. (2004) Biochem J 378 : 1023-1029
Rodriguez R, et al. (2003) Biochem J 374 : 269-280

Aliases: 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody, 1-phosphatidylinositol-4 antibody, 5-bisphosphate phosphodiesterase gamma-2 antibody, EC 3.1.4.11 antibody, Phosphoinositide phospholipase C antibody, Phosphoinositide phospholipase C-gamma-2 antibody, Phospholipase C gamma 2 antibody, Phospholipase C, gamma 2 (phosphatidylinositol specific) antibody, Phospholipase C-gamma-2 antibody, Phospholipase C-IV antibody, PLC 2 antibody, PLC gamma 2 antibody, PLC IV antibody, PLC-gamma-2 antibody, PLC-IV antibody, Plcg2 antibody, PLCG2_HUMAN antibody

UniProt: P16885

Pathways: RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling