ErbB2/Her2 antibody (pTyr1221, pTyr1222)

Catalog No. ABIN7139094

The Rabbit Polyclonal anti-ErbB2/Her2 antibody has been validated for WB, ELISA and IF. It is suitable to detect ErbB2/Her2 in samples from Human.

Quick Overview for ErbB2/Her2 antibody (pTyr1221, pTyr1222) (ABIN7139094)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-ErbB2/Her2 Antibody

Binding Specificity: pTyr1221, pTyr1222

Cross-Reactivity: Human

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine1221/1222 (N-L-Y(p)-Y(p)-W) derived from Human HER2.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000, IF:1:100-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: ERBB2

Background:

Background:

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin.

Marone R, et al. (2004) Nat Cell Biol, 6(6): 515-22.
Ren Z, et al. (2002) J Biol Chem, 277(41): 38486-93.

Aliases: Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody, C erb B2/neu protein antibody, CD340 antibody, CD340 antigen antibody, Cerb B2/neu protein antibody, CerbB2 antibody, Erb b2 receptor tyrosine kinase 2 antibody, ErbB-2 proto-oncogene antibody, ERBB2 antibody, ERBB2_HUMAN antibody, HER 2 antibody, HER 2/NEU antibody, HER2 antibody, Herstatin antibody, Human epidermal growth factor receptor 2 antibody, Metastatic lymph node gene 19 protein antibody, MLN 19 antibody, MLN19 antibody, NEU antibody, NEU proto oncogene antibody, Neuro/glioblastoma derived oncogene homolog antibody, Neuroblastoma/glioblastoma derived oncogene homolog antibody, NGL antibody, p185erbB2 antibody, Proto-oncogene c-ErbB-2 antibody, Proto-oncogene Neu antibody, Receptor tyrosine-protein kinase erbB-2 antibody, TKR1 antibody, Tyrosine kinase type cell surface receptor HER2 antibody, Tyrosine kinase-type cell surface receptor HER2 antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody, V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody

UniProt: P04626

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development