AJUBA antibody (AA 61-77) (Biotin)

Catalog No. ABIN7139905

This anti-AJUBA antibody is a Rabbit Polyclonal antibody detecting AJUBA in ELISA. Suitable for Human.

Quick Overview for AJUBA antibody (AA 61-77) (Biotin) (ABIN7139905)

Target: AJUBA (Ajuba LIM Protein (AJUBA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AJUBA antibody is conjugated to Biotin

Application: ELISA

Product Details anti-AJUBA Antibody (Biotin)

Binding Specificity: AA 61-77

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Peptide sequence from Human LIM domain-containing protein ajuba protein (61-77AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AJUBA

Target: AJUBA (Ajuba LIM Protein (AJUBA))

Alternative Name: AJUBA

Background:

Background: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Aliases: AJUBA antibody, JUB antibody, LIM domain-containing protein ajuba antibody

UniProt: Q96IF1

Pathways: Chromatin Binding, Cell-Cell Junction Organization