CBR1 antibody

Catalog No. ABIN7140302

This Mouse Monoclonal antibody specifically detects CBR1 in WB, ELISA and ICC. It exhibits reactivity toward Human.

Quick Overview for CBR1 antibody (ABIN7140302)

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-CBR1 Antibody

Cross-Reactivity: Human

Purification: Affinity purified

Immunogen: Purified recombinant human CBR1 protein fragments expressed in E.coli

Isotype: IgG1, IgG1 kappa

Application Details

Application Notes: Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified mouse monoclonal in PBS( pH 7.4)containing with 0.2 % sodium azide,50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CBR1

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Alternative Name: CBR1

Background:

Background: NADPH-dependent reductase with broad substrate specificity.Catalyzes the reduction of a wide variety of carbonyl compounds including quinones,prostaglandins, menadione,plus various xenobiotics.Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha.Can bind glutathione,which explains its higher affinity for glutathione-conjugated substrates.Catalyzes the reduction of S-nitrosoglutathione.

Aliases: 15 hydroxyprostaglandin dehydrogenase [NADP+], 15-hydroxyprostaglandin dehydrogenase [NADP+], Carbonyl reductase [NADPH] 1, Carbonyl Reductase 1, CBR 1, CBR1, CBR1_HUMAN, CRN, NADPH dependent carbonyl reductase 1, NADPH-dependent carbonyl reductase 1,

UniProt: P16152