RABAC1 antibody (AA 16-299)

Catalog No. ABIN7140908

This Rabbit Polyclonal antibody specifically detects RABAC1 in ELISA and WB. It exhibits reactivity toward Candida albicans.

Quick Overview for RABAC1 antibody (AA 16-299) (ABIN7140908)

Target: RABAC1 (Rab Acceptor 1 (Prenylated) (RABAC1))

Reactivity: Candida albicans

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RABAC1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-RABAC1 Antibody

Binding Specificity: AA 16-299

Cross-Reactivity: Candida albicans

Purification: >95%, Protein G purified

Immunogen: Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RABAC1

Target: RABAC1 (Rab Acceptor 1 (Prenylated) (RABAC1))

Alternative Name: PRA1

Background:

Background: Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages.

Aliases: PRA1 antibody, FBP1 antibody, CAALFM_C406980WA antibody, CaO19.10623 antibody, CaO19.3111 antibody, pH -regulated antigen PRA1 antibody, 58 kDa fibrinogen-binding mannoprotein antibody

UniProt: P87020

Pathways: Chromatin Binding