P4HB antibody (AA 20-509) (Biotin)

Catalog No. ABIN7141114

This anti-P4HB antibody is a Rabbit Polyclonal antibody detecting P4HB in ELISA. Suitable for Chinese Hamster.

Quick Overview for P4HB antibody (AA 20-509) (Biotin) (ABIN7141114)

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Reactivity: Chinese Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P4HB antibody is conjugated to Biotin

Application: ELISA

Product Details anti-P4HB Antibody (Biotin)

Binding Specificity: AA 20-509

Cross-Reactivity: Chinese Hamster

Purification: >95%, Protein G purified

Immunogen: Recombinant Cricetulus griseus Protein disulfide-isomerase protein (20-509AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for P4HB

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Alternative Name: P4HB

Background:

Background: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9, the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Aliases: P4HB antibody, PDIA1Protein disulfide-isomerase antibody, PDI antibody, EC 5.3.4.1 antibody, Prolyl 4-hydroxylase subunit beta antibody, p58 antibody

UniProt: Q8R4U2

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism