Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) antibody (Biotin)

Catalog No. ABIN7141317

The Rabbit Polyclonal anti- antibody has been validated for ELISA. It is suitable to detect in samples from Epstein-Barr Virus (EBV).

Quick Overview for Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 1-147) antibody (Biotin) (ABIN7141317)

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Reactivity: Epstein-Barr Virus (EBV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA

Product Details

Binding Specificity: AA 1-147

Virus Strain: strain B95-8

Purpose: LMP2 Antibody, Biotin conjugated

Cross-Reactivity: Epstein-Barr Virus (EBV)

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Alternative Name: Epstein-Barr virus (strain B95-8) (HHV-4) (Herpex simplex 4) LMP2

Background:

Background: Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.

Aliases: LMP2 antibody, Latent membrane protein 2 antibody, Terminal protein antibody

UniProt: P13285