RPL13A antibody (AA 63-190)

Catalog No. ABIN7142744

This Rabbit Polyclonal antibody specifically detects RPL13A in ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for RPL13A antibody (AA 63-190) (ABIN7142744)

Target: RPL13A (Ribosomal Protein L13a (RPL13A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPL13A antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-RPL13A Antibody

Binding Specificity: AA 63-190

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 60S ribosomal protein L13a protein (63-190AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RPL13A

Target: RPL13A (Ribosomal Protein L13a (RPL13A))

Alternative Name: RPL13A

Background:

Background: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3\'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.

Aliases: RPL13A antibody, 60S ribosomal protein L13a antibody, 23 kDa highly basic protein antibody, Large ribosomal subunit protein uL13 antibody

UniProt: P40429