NUDT1 antibody (AA 49-82)

Catalog No. ABIN7142858

This Rabbit Polyclonal antibody specifically detects NUDT1 in IHC, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for NUDT1 antibody (AA 49-82) (ABIN7142858)

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDT1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-NUDT1 Antibody

Binding Specificity: AA 49-82

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 7,8-dihydro-8-oxoguanine triphosphatase protein (49-82AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NUDT1

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Alternative Name: NUDT1

Background:

Background: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Aliases: 2-hydroxy-dATP diphosphatase antibody, 7 8 dihydro 8 oxoguanine triphosphatase antibody, 7 antibody, 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody, 8 oxo 7 8 dihydroguanosine triphosphatase antibody, 8 oxo dGTPase antibody, 8-dihydro-8-oxoguanine triphosphatase antibody, 8-oxo-dGTPase antibody, 8ODP_HUMAN antibody, MTH 1 antibody, MTH1 antibody, MutT human homolog 1 antibody, Nucleoside diphosphate linked moiety X motif 1 antibody, Nucleoside diphosphate linked moiety X type motif 1 antibody, Nucleoside diphosphate-linked moiety X motif 1 antibody, Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody, Nudix hydrolase 1 antibody, Nudix motif 1 antibody, Nudix type motif 1 antibody, NUDT 1 antibody, Nudt1 antibody

UniProt: P36639