Actin-Like 6B antibody (AA 1-280)

Catalog No. ABIN7143053

This Rabbit Polyclonal antibody specifically detects Actin-Like 6B in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Actin-Like 6B antibody (AA 1-280) (ABIN7143053)

Target: Actin-Like 6B (ACTL6B)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Actin-Like 6B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Actin-Like 6B Antibody

Binding Specificity: AA 1-280

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Actin-like protein 6B protein (1-280AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Actin-Like 6B

Target: Actin-Like 6B (ACTL6B)

Alternative Name: ACTL6B

Background:

Background: Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth .

Aliases: 53 kDa BRG1 associated factor B antibody, 53 kDa BRG1-associated factor B antibody, ACL 6B antibody, ACL6B antibody, ACL6B_HUMAN antibody, Actin like 6 antibody, Actin like protein 6B antibody, Actin like protein6B antibody, Actin related protein antibody, Actin related protein Baf53b antibody, actin-like 6B antibody, Actin-like protein 6B antibody, Actin-related protein Baf53b antibody, Actl 6 antibody, ACTL 6B antibody, Actl6 antibody, ACTL6 B antibody, Actl6b antibody, Arp Na antibody, ArpN a antibody, ArpN alpha antibody, ArpNa antibody, ArpNalpha antibody, Baf 53b antibody, BAF53B antibody, BRG1-associated factor 53B antibody

UniProt: O94805