MOCS3 antibody (AA 271-460)

Catalog No. ABIN7143362

This Rabbit Polyclonal antibody specifically detects MOCS3 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for MOCS3 antibody (AA 271-460) (ABIN7143362)

Target: MOCS3 (Molybdenum Cofactor Synthesis 3 (MOCS3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MOCS3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MOCS3 Antibody

Binding Specificity: AA 271-460

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Adenylyltransferase and sulfurtransferase MOCS3 protein (271-460AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MOCS3

Target: MOCS3 (Molybdenum Cofactor Synthesis 3 (MOCS3))

Alternative Name: MOCS3

Background:

Background: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor, NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

Aliases: Adenylyltransferase MOCS3 antibody, dJ914P20.3 antibody, MGC9252 antibody, MOCS 3 antibody, MOCS3 antibody, MOCS3_HUMAN antibody, Molybdenum cofactor synthesis 3 antibody, Molybdenum cofactor synthesis protein 3 antibody, Molybdopterin synthase sulfurylase antibody, Molybdopterin-synthase sulfurtransferase antibody, MPT synthase sulfurylase antibody, Sulfur carrier protein MOCS2A adenylyltransferase antibody, Sulfur carrier protein MOCS2A sulfurtransferase antibody, Sulfurtransferase MOCS3 antibody, UBA 4 antibody, UBA4 ubiquitin activating enzyme E1 homolog antibody, UBA4 antibody

UniProt: O95396