AFG3L2 antibody (AA 550-759)

Catalog No. ABIN7143582

The Rabbit Polyclonal anti-AFG3L2 antibody has been validated for WB, ELISA and IHC. It is suitable to detect AFG3L2 in samples from Human.

Quick Overview for AFG3L2 antibody (AA 550-759) (ABIN7143582)

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFG3L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-AFG3L2 Antibody

Binding Specificity: AA 550-759

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human AFG3-like protein 2 protein (550-759AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AFG3L2

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Alternative Name: AFG3L2

Background:

Background: ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form (By similarity).

Aliases: AFG3 (ATPase family gene 3, yeast) like 2 antibody, AFG3 ATPase family gene 3 like 2 (yeast) antibody, AFG3 ATPase family gene 3 like 2 antibody, AFG3 like protein 2 antibody, AFG3-like protein 2 antibody, AFG32_HUMAN antibody, AFG3L2 antibody, ATPase family gene 3 like 2 antibody, ATPase family gene 3 yeast antibody, EC 3.4.24.- antibody, FLJ25993 antibody, Paraplegin like protein antibody, Paraplegin-like protein antibody, SCA28 antibody, Spinocerebellar ataxia 28 antibody

UniProt: Q9Y4W6

Pathways: Skeletal Muscle Fiber Development