ASIP antibody (AA 23-112)

Catalog No. ABIN7143597

The Rabbit Polyclonal anti-ASIP antibody has been validated for ELISA, IHC and IF. It is suitable to detect ASIP in samples from Human.

Quick Overview for ASIP antibody (AA 23-112) (ABIN7143597)

Target: ASIP (Agouti Signaling Protein (ASIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASIP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ASIP Antibody

Binding Specificity: AA 23-112

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Agouti-signaling protein (23-112AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ASIP

Target: ASIP (Agouti Signaling Protein (ASIP))

Alternative Name: ASIP

Background:

Background: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Aliases: ASIP antibody, AGTI antibody, AGTIL antibody, ASP antibody, Agouti-signaling protein antibody, ASP antibody, Agouti switch protein antibody

UniProt: P42127

Pathways: Cell-Cell Junction Organization, Feeding Behaviour