alpha 2 Macroglobulin antibody (AA 1216-1467) (Biotin)

Catalog No. ABIN7143791

This Rabbit Polyclonal antibody specifically detects alpha 2 Macroglobulin in ELISA. It exhibits reactivity toward Human.

Quick Overview for alpha 2 Macroglobulin antibody (AA 1216-1467) (Biotin) (ABIN7143791)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha 2 Macroglobulin antibody is conjugated to Biotin

Application: ELISA

Product Details anti-alpha 2 Macroglobulin Antibody (Biotin)

Binding Specificity: AA 1216-1467

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Alpha-2-macroglobulin protein (1216-1467AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: A2M

Background:

Background: Is able to inhibit all four classes of proteinases by a unique \'trapping\' mechanism. This protein has a peptide stretch, called the \'bait region\' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Aliases: A2m antibody, A2MG_HUMAN antibody, Alpha 2 M antibody, Alpha 2M antibody, Alpha-2-M antibody, Alpha-2-macroglobulin antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody, CPAMD5 antibody, DKFZp779B086 antibody, FWP007 antibody, S863 7 antibody

UniProt: P01023

Pathways: Lipid Metabolism