AIMP1 antibody (AA 25-180) (HRP)

Catalog No. ABIN7143998

This Rabbit Polyclonal antibody specifically detects AIMP1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for AIMP1 antibody (AA 25-180) (HRP) (ABIN7143998)

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIMP1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-AIMP1 Antibody (HRP)

Binding Specificity: AA 25-180

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 protein (25-180AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AIMP1

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Alternative Name: AIMP1

Background:

Background: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Aliases: AIMP 1 antibody, Aimp1 antibody, AIMP1/p43 antibody, AIMP1_HUMAN antibody, Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 antibody, ARS interacting multifunctional protein 1 antibody, EMAP 2 antibody, EMAP-2 antibody, EMAP-II antibody, EMAP2 antibody, EMAPII antibody, Endothelial monocyte activating polypeptide 2 antibody, Endothelial monocyte activating polypeptide antibody, Endothelial monocyte-activating polypeptide 2 antibody, Endothelial monocyte-activating polypeptide II antibody, HLD3 antibody, Multisynthase complex auxiliary component p43 antibody, Multisynthetase complex auxiliary component p43 antibody, OTTHUMP00000219673 antibody, p43 antibody, Scye 1 antibody, Scye1 antibody, Scye1, formerly antibody, Small inducible cytokine subfamily E member 1 antibody, Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) antibody, Small inducible cytokine subfamily E, member 1, formerly antibody

UniProt: Q12904