DDX42 antibody (AA 519-819) (Biotin)

Catalog No. ABIN7144991

This Rabbit Polyclonal antibody specifically detects DDX42 in ELISA. It exhibits reactivity toward Human.

Quick Overview for DDX42 antibody (AA 519-819) (Biotin) (ABIN7144991)

Target: DDX42 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 42 (DDX42))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDX42 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-DDX42 Antibody (Biotin)

Binding Specificity: AA 519-819

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human ATP-dependent RNA helicase DDX42 protein (519-819AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DDX42

Target: DDX42 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 42 (DDX42))

Alternative Name: DDX42

Background:

Background: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.

Aliases: DDX42ATP-dependent RNA helicase DDX42 antibody, EC 3.6.4.13 antibody, DEAD box protein 42 antibody, RNA helicase-like protein antibody, RHELP antibody, RNA helicase-related protein antibody, RNAHP antibody, SF3b DEAD box protein antibody, Splicing factor 3B-associated 125 kDa protein antibody, SF3b125 antibody

UniProt: Q86XP3