AIRE antibody (AA 39-108) (HRP)

Catalog No. ABIN7145090

This Rabbit Polyclonal antibody specifically detects AIRE in ELISA. It exhibits reactivity toward Human.

Quick Overview for AIRE antibody (AA 39-108) (HRP) (ABIN7145090)

Target: AIRE (Autoimmune Regulator (AIRE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIRE antibody is conjugated to HRP

Application: ELISA

Product Details anti-AIRE Antibody (HRP)

Binding Specificity: AA 39-108

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Autoimmune regulator protein (39-108AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for AIRE

Target: AIRE (Autoimmune Regulator (AIRE))

Alternative Name: AIRE

Background:

Background: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment, the preferred motif is a tandem repeat of 5\'-. ATTGGTTA-3\' combined with a 5\'-TTATTA-3\' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at \'Lys-4\', not phosphorylated at \'Thr-3\' and not methylated at \'Arg-2\'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

Aliases: AIRE antibody, AIRE_HUMAN antibody, AIRE1 antibody, APECED antibody, APECED protein antibody, APS1 antibody, APSI antibody, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody, Autoimmune regulator antibody, Autoimmune regulator protein antibody, PGA1 antibody

UniProt: O43918

Pathways: Chromatin Binding