CD22 antibody (AA 708-847)

Catalog No. ABIN7145176

Product Details anti-CD22 Antibody

Target: CD22 (CD22 Molecule (CD22))

Binding Specificity: AA 708-847

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD22 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human B-cell receptor CD22 protein (708-847AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD22

Target: CD22 (CD22 Molecule (CD22))

Alternative Name: CD22 (CD22 Products)

Background:

Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Aliases: B cell receptor CD22 precursor antibody, B lymphocyte cell adhesion molecule antibody, B-cell receptor CD22 antibody, B-lymphocyte cell adhesion molecule antibody, BL CAM antibody, BL-CAM antibody, BLCAM antibody, CD 22 antibody, CD22 antibody, CD22 antigen antibody, CD22 Molecule antibody, CD22 protein antibody, CD22_HUMAN antibody, Lectin 2 antibody, Leu14 antibody, Lyb8 antibody, MGC130020 antibody, sialic acid binding Ig like lectin 2 antibody, Sialic acid binding immunoglobulin like lectin 2 antibody, Sialic acid-binding Ig-like lectin 2 antibody, SIGLEC 2 antibody, Siglec-2 antibody, SIGLEC2 antibody, T cell surface antigen Leu 14 antibody, T-cell surface antigen Leu-14 antibody

UniProt: P20273