CD22 antibody (CD22 Molecule) (AA 621-725)

Details for Product anti-CD22 Antibody No. ABIN1724887
Antigen
Epitope
AA 621-725
25
20
15
9
9
7
6
6
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
422
149
44
15
4
3
3
3
3
2
Host
Mouse
297
152
72
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CD22 antibody is un-conjugated
65
50
34
25
7
7
6
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
333
179
104
103
95
45
34
22
14
12
12
11
4
4
3
3
2
2
2
1
Options
Immunogen Purified recombinant fragment of human CD22 (AA 621-725) expressed in E. Coli.
Clone 1A3A11
Isotype IgG1
Purification Purified
Antigen
Alternative Name CD22 (CD22 Antibody Abstract)
Background CD22 may be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules ,
Molecular Weight 95.3 kDa
Gene ID 933
HGNC 933
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-CD22 Molecule (CD22) (AA 621-725) antibody (ABIN1724887) anti-CD22 Molecule (CD22) (AA 621-725) antibody (Image 1)
Image no. 2 for anti-CD22 Molecule (CD22) (AA 621-725) antibody (ABIN1724887) anti-CD22 Molecule (CD22) (AA 621-725) antibody (Image 2)
Image no. 3 for anti-CD22 Molecule (CD22) (AA 621-725) antibody (ABIN1724887) anti-CD22 Molecule (CD22) (AA 621-725) antibody (Image 3)
Image no. 4 for anti-CD22 Molecule (CD22) (AA 621-725) antibody (ABIN1724887) anti-CD22 Molecule (CD22) (AA 621-725) antibody (Image 4)
Image no. 5 for anti-CD22 Molecule (CD22) (AA 621-725) antibody (ABIN1724887) anti-CD22 Molecule (CD22) (AA 621-725) antibody (Image 5)
Product cited in: Tuscano, Kato, Pearson, Xiong, Newell, Ma, Gandara, ODonnell: "CD22 antigen is broadly expressed on lung cancer cells and is a target for antibody-based therapy." in: Cancer research, Vol. 72, Issue 21, pp. 5556-65, 2012 (PubMed).

Kawasaki, Rademacher, Paulson: "CD22 regulates adaptive and innate immune responses of B cells." in: Journal of innate immunity, Vol. 3, Issue 4, pp. 411-9, 2011 (PubMed).