BAZ2A antibody (AA 97-266)

Catalog No. ABIN7145796

The Rabbit Polyclonal anti-BAZ2A antibody has been validated for ELISA and IF. It is suitable to detect BAZ2A in samples from Human.

Quick Overview for BAZ2A antibody (AA 97-266) (ABIN7145796)

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAZ2A antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-BAZ2A Antibody

Binding Specificity: AA 97-266

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bromodomain adjacent to zinc finger domain protein 2A protein (97-266AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BAZ2A

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Alternative Name: BAZ2A

Background:

Background: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on \\\'Lys-16\\\' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

Aliases: BAZ2A antibody, KIAA0314 antibody, TIP5Bromodomain adjacent to zinc finger domain protein 2A antibody, Transcription termination factor I-interacting protein 5 antibody, TTF-I-interacting protein 5 antibody, Tip5 antibody, hWALp3 antibody

UniProt: Q9UIF9