ORAI1 antibody (AA 1-87) (Biotin)

Catalog No. ABIN7146307

This anti-ORAI1 antibody is a Rabbit Polyclonal antibody detecting ORAI1 in ELISA. Suitable for Human.

Quick Overview for ORAI1 antibody (AA 1-87) (Biotin) (ABIN7146307)

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORAI1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-ORAI1 Antibody (Biotin)

Binding Specificity: AA 1-87

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Calcium release-activated calcium channel protein 1 protein (1-87AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ORAI1

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Alternative Name: ORAI1

Background:

Background: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).

Aliases: Calcium release activated calcium channel protein 1 antibody, Calcium release activated calcium modulator 1 antibody, Calcium release-activated calcium channel protein 1 antibody, CRACM 1 antibody, CRACM1 antibody, CRCM1 antibody, CRCM1_HUMAN antibody, FLJ14466 antibody, Orai 1 antibody, ORAI calcium release activated calcium modulator 1 antibody, orai1 antibody, ORAT1 antibody, Protein orai 1 antibody, Protein orai-1 antibody, TMEM 142A antibody, TMEM142A antibody, Transmembrane protein 142A antibody

UniProt: Q96D31

Pathways: TCR Signaling, BCR Signaling