CALCOCO1 antibody (AA 462-691)

Catalog No. ABIN7146346

This anti-CALCOCO1 antibody is a Rabbit Polyclonal antibody detecting CALCOCO1 in WB, IHC and ELISA. Suitable for Human.

Quick Overview for CALCOCO1 antibody (AA 462-691) (ABIN7146346)

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CALCOCO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CALCOCO1 Antibody

Binding Specificity: AA 462-691

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Calcium-binding and coiled-coil domain-containing protein 1 protein (462-691AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CALCOCO1

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Alternative Name: CALCOCO1

Background:

Background: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Aliases: CALCOCO1 antibody, KIAA1536 antibody, PP13275 antibody, UNQ2436/PRO4996Calcium-binding and coiled-coil domain-containing protein 1 antibody, Calphoglin antibody, Coiled-coil coactivator protein antibody, Sarcoma antigen NY-SAR-3 antibody

UniProt: Q9P1Z2

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Chromatin Binding