CALCOCO2 antibody (AA 137-446)

Catalog No. ABIN7146349

This anti-CALCOCO2 antibody is a Rabbit Polyclonal antibody detecting CALCOCO2 in WB, ELISA, IHC and IP. Suitable for Human.

Quick Overview for CALCOCO2 antibody (AA 137-446) (ABIN7146349)

Target: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CALCOCO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-CALCOCO2 Antibody

Binding Specificity: AA 137-446

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CALCOCO2

Target: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Alternative Name: CALCOCO2

Background:

Background: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).

Aliases: Antigen nuclear dot 52 kDa protein antibody, CACO2_HUMAN antibody, Calcium binding and coiled coil domain 2 antibody, Calcium binding and coiled coil domain containing protein 2 antibody, Calcium-binding and coiled-coil domain-containing protein 2 antibody, CALCOCO 2 antibody, CALCOCO2 antibody, MGC17318 antibody, NDP52 antibody, Nuclear domain 10 protein 52 antibody, Nuclear domain 10 protein antibody, Nuclear domain 10 protein NDP52 antibody, Nuclear domain protein 52 antibody, Nuclear dot protein 52 antibody, OTTHUMP00000218344 antibody, OTTHUMP00000218345 antibody, OTTHUMP00000218346 antibody, OTTHUMP00000218347 antibody, OTTHUMP00000218349 antibody, OTTHUMP00000218351 antibody

UniProt: Q13137