COMP antibody (AA 20-160)

Catalog No. ABIN7146850

This anti-COMP antibody is a Rabbit Polyclonal antibody detecting COMP in WB and ELISA. Suitable for Human.

Quick Overview for COMP antibody (AA 20-160) (ABIN7146850)

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-COMP Antibody

Binding Specificity: AA 20-160

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Cartilage oligomeric matrix protein (20-160AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COMP

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Alternative Name: COMP

Background:

Background: May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Aliases: cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) antibody, Cartilage oligomeric matrix protein antibody, Cartilage oligomeric matrix protein precursor antibody, COMP antibody, COMP_HUMAN antibody, EDM 1 antibody, EDM1 antibody, EPD 1 antibody, EPD1 antibody, Epiphyseal dysplasia 1 antibody, Epiphyseal dysplasia 1 multiple antibody, Epiphyseal dysplasia multiple 1 antibody, MED antibody, MGC13181 antibody, MGC149768 antibody, PSACH antibody, pseudoachondroplasia (epiphyseal dysplasia 1, multiple) antibody, Pseudoachondroplasia antibody, THBS 5 antibody, THBS5 antibody, Thrombospondin 5 antibody, Thrombospondin-5 antibody, Thrombospondin5 antibody, TSP5 antibody

UniProt: P49747