Casein Kinase 1 delta antibody (Isoform delta)

Catalog No. ABIN7146858

The Rabbit Polyclonal anti-Casein Kinase 1 delta antibody is suitable to detect Casein Kinase 1 delta in samples from Human. It has been validated for WB, ELISA, IHC, IP and IF.

Quick Overview for Casein Kinase 1 delta antibody (Isoform delta) (ABIN7146858)

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Casein Kinase 1 delta antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-Casein Kinase 1 delta Antibody

Binding Specificity: AA 152-398, Isoform delta

Purpose: CSNK1D Antibody

Cross-Reactivity: Mouse, Rat

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Casein kinase I isoform delta protein (152-398AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Casein Kinase 1 delta

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Alternative Name: CSNK1D

Background:

Background: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Aliases: Casein Kinase 1 delta antibody, Casein kinase I delta isoform antibody, Casein kinase I isoform delta antibody, CKI delta antibody, CKI-delta antibody, CKId antibody, CKIdelta antibody, CSNK 1D antibody, CSNK1D antibody, HCKID antibody, KC1D_HUMAN antibody, Protein kinase CK1 delta antibody

UniProt: P48730

Pathways: Hedgehog Signaling, M Phase