CDK5RAP2 antibody (Regulatory Subunit)

Catalog No. ABIN7147230

The Rabbit Polyclonal anti-CDK5RAP2 antibody has been validated for ELISA, IHC and IF. It is suitable to detect CDK5RAP2 in samples from Human.

Quick Overview for CDK5RAP2 antibody (Regulatory Subunit) (ABIN7147230)

Target: CDK5RAP2 (CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK5RAP2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CDK5RAP2 Antibody

Binding Specificity: AA 996-1111, Regulatory Subunit

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human CDK5 regulatory subunit-associated protein 2 protein (996-1111AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CDK5RAP2

Target: CDK5RAP2 (CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2))

Alternative Name: CDK5RAP2

Background:

Background: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of a gamma-tubulin ring complex onto centrosomes (PubMed:26485573).

Aliases: C48 antibody, CDK5 activator-binding protein C48 antibody, CDK5 regulatory subunit associated protein 2 antibody, CDK5 regulatory subunit-associated protein 2 antibody, CDK5RAP2 antibody, centrosomal protein 215 kDa antibody, Centrosome-associated protein 215 antibody, CEP215 antibody, CK5P2_HUMAN antibody, MCPH3 antibody

UniProt: Q96SN8

Pathways: M Phase, SARS-CoV-2 Protein Interactome