CHMP6 antibody (AA 2-201) (FITC)

Catalog No. ABIN7147535

This Rabbit Polyclonal antibody specifically detects CHMP6 in . It exhibits reactivity toward Human.

Quick Overview for CHMP6 antibody (AA 2-201) (FITC) (ABIN7147535)

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP6 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-CHMP6 Antibody (FITC)

Binding Specificity: AA 2-201

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Charged multivesicular body protein 6 protein (2-201AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHMP6

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Alternative Name: CHMP6

Background:

Background: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

Aliases: Charged multivesicular body protein 6 antibody, chmp6 antibody, CHMP6_HUMAN antibody, Chromatin modifying protein 6 antibody, Chromatin-modifying protein 6 antibody, FLJ11749 antibody, hVps 20 antibody, hVps20 antibody, novel SNF7 protein antibody, OTTMUSP00000004363 antibody, RGD1565325 antibody, RP24 225K18.4 antibody, Vacuolar protein sorting associated protein 20 antibody, Vacuolar protein sorting-associated protein 20 antibody, Vps 20 antibody, Vps20 antibody

UniProt: Q96FZ7