INO80 antibody (AA 1365-1495)

Catalog No. ABIN7147693

This anti-INO80 antibody is a Rabbit Polyclonal antibody detecting INO80 in ELISA, WB and IF. Suitable for Human.

Quick Overview for INO80 antibody (AA 1365-1495) (ABIN7147693)

Target: INO80 (INO80 Homolog (INO80))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INO80 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-INO80 Antibody

Binding Specificity: AA 1365-1495

Purpose: INO80 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Chromatin-remodeling ATPase INO80 protein (1365-1495AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for INO80

Target: INO80 (INO80 Homolog (INO80))

Alternative Name: INO80

Background:

Background: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).

Aliases: DNA helicase INO80 antibody, hINO80 antibody, homolog of yeast INO80 antibody, INO80 antibody, INO80 complex subunit A antibody, INO80 homolog antibody, INO80_HUMAN antibody, INO80A antibody, INOC1 antibody, KIAA1259 antibody, Putative DNA helicase INO80 complex homolog 1 antibody

UniProt: Q9ULG1

Pathways: Positive Regulation of Response to DNA Damage Stimulus