CBX5 antibody (AA 1-191) (Biotin)

Catalog No. ABIN7147706

This Rabbit Polyclonal antibody specifically detects CBX5 in ELISA. It exhibits reactivity toward Human.

Quick Overview for CBX5 antibody (AA 1-191) (Biotin) (ABIN7147706)

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX5 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CBX5 Antibody (Biotin)

Binding Specificity: AA 1-191

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Chromobox protein homolog 5 protein (1-191AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CBX5

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Alternative Name: CBX5

Background:

Background: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

Aliases: Antigen p25 antibody, CBX5 antibody, CBX5_HUMAN antibody, CG8409 antibody, Chromobox 5 antibody, Chromobox homolog 5 (HP1 alpha homolog, Drosophila) antibody, Chromobox homolog 5 antibody, Chromobox protein homolog 5 antibody, Epididymis luminal protein 25 antibody, HEL25 antibody, Heterochromatin protein 1 alpha antibody, Heterochromatin protein 1 antibody, Heterochromatin protein 1 homolog alpha antibody, HP1 alpha antibody, HP1 alpha homolog antibody, HP1 antibody, HP1A antibody, HP1Hs alpha antibody, Su(var)205 antibody

UniProt: P45973