CHD5 antibody (AA 1600-1699) (Biotin)

Catalog No. ABIN7147725

The Rabbit Polyclonal anti-CHD5 antibody has been validated for ELISA. It is suitable to detect CHD5 in samples from Human.

Quick Overview for CHD5 antibody (AA 1600-1699) (Biotin) (ABIN7147725)

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHD5 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CHD5 Antibody (Biotin)

Binding Specificity: AA 1600-1699

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Chromodomain-helicase-DNA-binding protein 5 protein (1600-1699AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHD5

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Alternative Name: CHD5

Background:

Background: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated \'Lys-27\' (H3K27me3) and non-methylated \'Lys-4\' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at \'Lys-27\' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

Aliases: ATP-dependent helicase CHD5 antibody, CHD 5 antibody, CHD-5 antibody, CHD5 antibody, CHD5_HUMAN antibody, Chromodomain-helicase-DNA-binding protein 5 antibody, DKFZp434N231 antibody, KIAA0444 antibody, RP1-233K16.2 antibody

UniProt: Q8TDI0