CBP antibody (AA 2217-2442) (FITC)

Catalog No. ABIN7148673

The Rabbit Polyclonal anti-CBP antibody has been validated for . It is suitable to detect CBP in samples from Human.

Quick Overview for CBP antibody (AA 2217-2442) (FITC) (ABIN7148673)

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBP antibody is conjugated to FITC

Application: Please inquire

Product Details anti-CBP Antibody (FITC)

Binding Specificity: AA 2217-2442

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human CREB-binding protein (2217-2442AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CBP

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Alternative Name: CREBBP

Background:

Background: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA, acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).

Aliases: CBP antibody, CBP_HUMAN antibody, CREB binding protein antibody, CREB-binding protein antibody, Crebbp antibody, Cyclic AMP responsive enhancer binding protein antibody, KAT3A antibody, RSTS antibody, RTS antibody, Rubinstein Taybi syndrome antibody

UniProt: Q92793

Pathways: TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha