CBP antibody (N-Term)

Catalog No. ABIN2781491

The Rabbit Polyclonal anti-CBP antibody (ABIN2781491) specifically detects CBP in IHC and WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit samples.

Quick Overview for CBP antibody (N-Term) (ABIN2781491)

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBP antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-CBP Antibody

Binding Specificity: N-Term

Purpose: CREBBP Antibody - N-terminal region

Sequence: TPAASQALNP QAQKQVGLAT SSPATSQTGP GICMNANFNQ THPGLLNSNS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CREBBP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CREBBP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43609-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CBP

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Alternative Name: CREBBP

Background:

Background Information: CREBBP is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.

Gene Name: CREB binding protein

Alternative Symbols: CBP, RSTS, KAT3A, MKHK1, RSTS1

Protein Name: CREBBP variant protein EMBL BAE06125.1

Molecular Weight: 261kDa

Gene ID: 1387

NCBI Accession: NP_001073315

UniProt: Q4LE28

Pathways: TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha