CDK13 antibody (AA 1-170)

Catalog No. ABIN7148855

This Rabbit Polyclonal antibody specifically detects CDK13 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for CDK13 antibody (AA 1-170) (ABIN7148855)

Target: CDK13 (Cyclin-Dependent Kinase 13 (CDK13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK13 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-CDK13 Antibody

Binding Specificity: AA 1-170

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cyclin-dependent kinase 13 protein (1-170AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CDK13

Target: CDK13 (Cyclin-Dependent Kinase 13 (CDK13))

Alternative Name: CDK13

Background:

Background: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at \'Lys-50\' and \'Lys-51\', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Aliases: CDC2 related protein kinase 5 antibody, CDC2-related protein kinase 5 antibody, CDC2L antibody, CDK13 antibody, CDK13_HUMAN antibody, cell division controller cholinesterase related antibody, cell division cycle 2 like 5 (cholinesterase related cell division controller) antibody, cell division cycle 2 like 5 antibody, Cell division cycle 2 like protein kinase 5 antibody, Cell division cycle 2-like protein kinase 5 antibody, Cell division protein kinase 13 antibody, CHED antibody, Cholinesterase related cell division controller antibody, Cholinesterase-related cell division controller antibody, cyclin dependent kinase 13 antibody, Cyclin-dependent kinase 13 antibody, hCDK13 antibody

UniProt: Q14004