CDK3 antibody (AA 220-297)

Catalog No. ABIN7148881

This anti-CDK3 antibody is a Rabbit Polyclonal antibody detecting CDK3 in ELISA and IHC. Suitable for Human.

Quick Overview for CDK3 antibody (AA 220-297) (ABIN7148881)

Target: CDK3 (Cyclin-Dependent Kinase 3 (CDK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-CDK3 Antibody

Binding Specificity: AA 220-297

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cyclin-dependent kinase 3 protein (220-297AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CDK3

Target: CDK3 (Cyclin-Dependent Kinase 3 (CDK3))

Alternative Name: CDK3

Background:

Background: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle, involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Aliases: Cdk 3 antibody, Cdk3 antibody, CDK3_HUMAN antibody, CDKN3 antibody, Cell division kinase 3 antibody, Cell division protein kinase 3 antibody, Cyclin dependent kinase 3 antibody, Cyclin-dependent kinase 3 antibody, OTTHUMP00000206828 antibody, p36 antibody

UniProt: Q00526

Pathways: Cell Division Cycle