CYP3A4 antibody (AA 259-441)

Catalog No. ABIN7149259

This anti-CYP3A4 antibody is a Rabbit Polyclonal antibody detecting CYP3A4 in WB, IHC, ELISA and IF. Suitable for Human.

Quick Overview for CYP3A4 antibody (AA 259-441) (ABIN7149259)

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP3A4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-CYP3A4 Antibody

Binding Specificity: AA 259-441

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cytochrome P450 3A4 protein (259-441AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CYP3A4

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Alternative Name: CYP3A4

Background:

Background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1\\\'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).

Aliases: 1,8-cineole 2-exo-monooxygenase antibody, Albendazole monooxygenase antibody, Albendazole sulfoxidase antibody, CP33 antibody, CP34 antibody, CP3A4_HUMAN antibody, CYP3 antibody, CYP3A antibody, CYP3A3 antibody, CYP3A4 antibody, CYPIIIA3 antibody, CYPIIIA4 antibody, Cytochrome P450 3A3 antibody, Cytochrome P450 3A4 antibody, Cytochrome P450 family 3 subfamily A polypeptide 4 antibody, Cytochrome P450 HLp antibody, Cytochrome P450 NF-25 antibody, Cytochrome P450 subfamily IIIA polypeptide 4 antibody, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 antibody, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 antibody, Cytochrome P450-PCN1 antibody, Glucocorticoid inducible P450 antibody, HLP antibody, MGC126680 antibody, NF 25 antibody, NF25 antibody, Nifedipine oxidase antibody, P450 III steroid inducible antibody, P450 PCN1 antibody, P450, family III antibody, P450C3 antibody, P450PCN1 antibody, Quinine 3 monooxygenase antibody, Quinine 3-monooxygenase antibody, Taurochenodeoxycholate 6 alpha hydroxylase antibody, Taurochenodeoxycholate 6-alpha-hydroxylase antibody

UniProt: P08684

Pathways: Steroid Hormone Biosynthesis